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Resource StructureDefinition/FHIR Server from package hl7.eu.fhir.idea4rc#current (235 ms)

Package hl7.eu.fhir.idea4rc
Type StructureDefinition
Id Id
FHIR Version R4
Source http://hl7.eu/fhir/ig/idea4rc/https://build.fhir.org/ig/hl7-eu/idea4rc/StructureDefinition-SystemicTreatment.html
Url http://hl7.eu/fhir/ig/idea4rc/StructureDefinition/SystemicTreatment
Version 0.1.0
Status draft
Date 2025-01-13T10:15:12+00:00
Name SystemicTreatmentI4RC
Title Systemic Treatment
Experimental False
Realm eu
Authority hl7
Description Systemic Treatment Maturity Level: 0 Draft
Type http://hl7.eu/fhir/ig/idea4rc/StructureDefinition/SystemicTreatment
Kind logical

Resources that use this resource

StructureDefinition
AdverseEvent Adverse Event
DrugsForTreatments Drugs for Treatments

Resources that this resource uses

StructureDefinition
Diagnosis Diagnosis
EpisodeEvent Episode Event

Narrative

Note: links and images are rebased to the (stated) source

Generated Narrative: StructureDefinition SystemicTreatment

NameFlagsCard.TypeDescription & Constraintsdoco
.. SystemicTreatment 0..*BaseSystemic Treatment
... diagnosisReference O1..*DiagnosisDiagnosis reference (M)
ObligationsActor
SHALL:handleHead and Neck
SHALL:handleSarcoma
... episodeEvent O1..*EpisodeEventEpisode Event reference (M)
ObligationsActor
SHALL:handleHead and Neck
SHALL:handleSarcoma
... systemicTreatmentHospital O1..*stringSystemicTreatment Hospital (M)
ObligationsActor
SHALL:handleHead and Neck
SHALL:handleSarcoma
... typeOfSystemicTreatment O1..*CodeableConcepttype of systemic treatment (M)
ObligationsActor
SHALL:handleHead and Neck
SHALL:handleSarcoma
... intent O0..*CodeableConceptIntent (O)
ObligationsActor
SHALL:handleHead and Neck
... setting O0..*CodeableConceptSetting (O)
ObligationsActor
SHALL:handleHead and Neck
... chemotherapyInfo O0..*CodeableConceptChemotherapy info (O)
ObligationsActor
SHALL:handleSarcoma
... startDateSystemicTreatment O1..*dateStart date systemic treatment (M)
ObligationsActor
SHALL:handleHead and Neck
SHALL:handleSarcoma
... endDateSystemicTreatment O1..*dateEnd date systemic treatment (M)
ObligationsActor
SHALL:handleHead and Neck
SHALL:handleSarcoma
... numberOfCycles O0..*QuantityNumber of cycles/ administrations (O)
ObligationsActor
SHALL:handleHead and Neck
SHALL:handleSarcoma
... regimen O0..*CodeableConceptRegimen (O)
ObligationsActor
SHALL:handleHead and Neck
SHALL:handleSarcoma
... startDateRegimenChanged O1..*dateStart date regimen changed (M)
ObligationsActor
SHALL:handleHead and Neck
... endDateRegimenChanged O1..*dateEnd date regimen changed (M)
ObligationsActor
SHALL:handleHead and Neck
... reasonForEndOfTreatment O1..*CodeableConceptReason for end of treatment (M)
ObligationsActor
SHALL:handleHead and Neck
SHALL:handleSarcoma
... treatmentResponse O1..*CodeableConceptTreatment response (based on imaging alone; no recist or other criteria) (M)
ObligationsActor
SHALL:handleHead and Neck
SHALL:handleSarcoma

doco Documentation for this format

Source

{
  "resourceType" : "StructureDefinition",
  "id" : "SystemicTreatment",
  "text" : {
    "status" : "extensions",
    "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p class=\"res-header-id\"><b>Generated Narrative: StructureDefinition SystemicTreatment</b></p><a name=\"SystemicTreatment\"> </a><a name=\"hcSystemicTreatment\"> </a><a name=\"SystemicTreatment-en-US\"> </a><table border=\"0\" cellpadding=\"0\" cellspacing=\"0\" style=\"border: 0px #F0F0F0 solid; font-size: 11px; font-family: verdana; vertical-align: top;\"><tr style=\"border: 1px #F0F0F0 solid; font-size: 11px; font-family: verdana; vertical-align: top\"><th style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; padding-top: 3px; padding-bottom: 3px\" class=\"hierarchy\"><a href=\"https://build.fhir.org/ig/FHIR/ig-guidance/readingIgs.html#table-views\" title=\"The logical name of the element\">Name</a></th><th style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; padding-top: 3px; padding-bottom: 3px\" class=\"hierarchy\"><a href=\"https://build.fhir.org/ig/FHIR/ig-guidance/readingIgs.html#table-views\" title=\"Information about the use of the element\">Flags</a></th><th style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; padding-top: 3px; padding-bottom: 3px\" class=\"hierarchy\"><a href=\"https://build.fhir.org/ig/FHIR/ig-guidance/readingIgs.html#table-views\" title=\"Minimum and Maximum # of times the element can appear in the instance\">Card.</a></th><th style=\"width: 100px\" class=\"hierarchy\"><a href=\"https://build.fhir.org/ig/FHIR/ig-guidance/readingIgs.html#table-views\" title=\"Reference to the type of the element\">Type</a></th><th style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; padding-top: 3px; padding-bottom: 3px\" class=\"hierarchy\"><a href=\"https://build.fhir.org/ig/FHIR/ig-guidance/readingIgs.html#table-views\" title=\"Additional information about the element\">Description &amp; Constraints</a><span style=\"float: right\"><a href=\"https://build.fhir.org/ig/FHIR/ig-guidance/readingIgs.html#table-views\" title=\"Legend for this format\"><img src=\"data:image/png;base64,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\" alt=\"doco\" style=\"background-color: inherit\"/></a></span></th></tr><tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white\"><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck1.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_element.gif\" alt=\".\" style=\"background-color: white; background-color: inherit\" title=\"Element\" class=\"hierarchy\"/> <a href=\"StructureDefinition-SystemicTreatment-definitions.html#SystemicTreatment\" title=\"Systemic Treatment\nMaturity Level: 0 Draft\">SystemicTreatment</a><a name=\"SystemicTreatment\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"/><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><span style=\"opacity: 0.5\">0</span><span style=\"opacity: 0.5\">..</span><span style=\"opacity: 0.5\">*</span></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a href=\"http://build.fhir.org/types.html#Base\">Base</a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">Systemic Treatment</td></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: #F7F7F7\"><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck10.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_resource.png\" alt=\".\" style=\"background-color: #F7F7F7; background-color: inherit\" title=\"Resource\" class=\"hierarchy\"/> <a href=\"StructureDefinition-SystemicTreatment-definitions.html#SystemicTreatment.diagnosisReference\" title=\"Diagnosis reference in case the treatment was done for baseline \">diagnosisReference</a><a name=\"SystemicTreatment.diagnosisReference\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><span style=\"padding-left: 3px; padding-right: 3px; color: white; background-color: red\" title=\"This element has obligations\">O</span></td><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">1..*</td><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a href=\"StructureDefinition-Diagnosis.html\">Diagnosis</a></td><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">Diagnosis reference (M)<br/><table class=\"grid\"><tr><td style=\"font-size: 11px\"><b>Obligations</b></td><td style=\"font-size: 11px\"><b>Actor</b></td></tr><tr><td style=\"font-size: 11px\"><b>SHALL</b>:<span title=\"obligation: handle\">handle</span></td><td style=\"font-size: 11px; opacity: 0.5;\"><a href=\"ActorDefinition-actor-headneck-i4rc.html\">Head and Neck</a></td></tr><tr><td style=\"font-size: 11px\"><b>SHALL</b>:<span title=\"obligation: handle\">handle</span></td><td style=\"font-size: 11px; opacity: 0.5;\"><a href=\"ActorDefinition-actor-sarcoma-i4rc.html\">Sarcoma</a></td></tr></table></td></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white\"><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck10.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_resource.png\" alt=\".\" style=\"background-color: white; background-color: inherit\" title=\"Resource\" class=\"hierarchy\"/> <a href=\"StructureDefinition-SystemicTreatment-definitions.html#SystemicTreatment.episodeEvent\" title=\"EpisodeEvent element containing the data regarding the patient's cancer \">episodeEvent</a><a name=\"SystemicTreatment.episodeEvent\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><span style=\"padding-left: 3px; padding-right: 3px; color: white; background-color: red\" title=\"This element has obligations\">O</span></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">1..*</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a href=\"StructureDefinition-EpisodeEvent.html\">EpisodeEvent</a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">Episode Event reference (M)<br/><table class=\"grid\"><tr><td style=\"font-size: 11px\"><b>Obligations</b></td><td style=\"font-size: 11px\"><b>Actor</b></td></tr><tr><td style=\"font-size: 11px\"><b>SHALL</b>:<span title=\"obligation: handle\">handle</span></td><td style=\"font-size: 11px; opacity: 0.5;\"><a href=\"ActorDefinition-actor-headneck-i4rc.html\">Head and Neck</a></td></tr><tr><td style=\"font-size: 11px\"><b>SHALL</b>:<span title=\"obligation: handle\">handle</span></td><td style=\"font-size: 11px; opacity: 0.5;\"><a href=\"ActorDefinition-actor-sarcoma-i4rc.html\">Sarcoma</a></td></tr></table></td></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: #F7F7F7\"><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck10.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_primitive.png\" alt=\".\" style=\"background-color: #F7F7F7; background-color: inherit\" title=\"Primitive Data Type\" class=\"hierarchy\"/> <a href=\"StructureDefinition-SystemicTreatment-definitions.html#SystemicTreatment.systemicTreatmentHospital\" title=\"In which hospital was the SystemicTreatment performed \">systemicTreatmentHospital</a><a name=\"SystemicTreatment.systemicTreatmentHospital\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><span style=\"padding-left: 3px; padding-right: 3px; color: white; background-color: red\" title=\"This element has obligations\">O</span></td><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">1..*</td><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a href=\"http://hl7.org/fhir/R4/datatypes.html#string\">string</a></td><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">SystemicTreatment Hospital (M)<br/><table class=\"grid\"><tr><td style=\"font-size: 11px\"><b>Obligations</b></td><td style=\"font-size: 11px\"><b>Actor</b></td></tr><tr><td style=\"font-size: 11px\"><b>SHALL</b>:<span title=\"obligation: handle\">handle</span></td><td style=\"font-size: 11px; opacity: 0.5;\"><a href=\"ActorDefinition-actor-headneck-i4rc.html\">Head and Neck</a></td></tr><tr><td style=\"font-size: 11px\"><b>SHALL</b>:<span title=\"obligation: handle\">handle</span></td><td style=\"font-size: 11px; opacity: 0.5;\"><a href=\"ActorDefinition-actor-sarcoma-i4rc.html\">Sarcoma</a></td></tr></table></td></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white\"><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck10.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_datatype.gif\" alt=\".\" style=\"background-color: white; background-color: inherit\" title=\"Data Type\" class=\"hierarchy\"/> <a href=\"StructureDefinition-SystemicTreatment-definitions.html#SystemicTreatment.typeOfSystemicTreatment\" title=\"Select the type of systemic treatment administered. It is possible to directly select the single treatment as appropriate. \nCheck Targeted therapy code\">typeOfSystemicTreatment</a><a name=\"SystemicTreatment.typeOfSystemicTreatment\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><span style=\"padding-left: 3px; padding-right: 3px; color: white; background-color: red\" title=\"This element has obligations\">O</span></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">1..*</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a href=\"http://hl7.org/fhir/R4/datatypes.html#CodeableConcept\">CodeableConcept</a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">type of systemic treatment (M)<br/><table class=\"grid\"><tr><td style=\"font-size: 11px\"><b>Obligations</b></td><td style=\"font-size: 11px\"><b>Actor</b></td></tr><tr><td style=\"font-size: 11px\"><b>SHALL</b>:<span title=\"obligation: handle\">handle</span></td><td style=\"font-size: 11px; opacity: 0.5;\"><a href=\"ActorDefinition-actor-headneck-i4rc.html\">Head and Neck</a></td></tr><tr><td style=\"font-size: 11px\"><b>SHALL</b>:<span title=\"obligation: handle\">handle</span></td><td style=\"font-size: 11px; opacity: 0.5;\"><a href=\"ActorDefinition-actor-sarcoma-i4rc.html\">Sarcoma</a></td></tr></table></td></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: #F7F7F7\"><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck10.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_datatype.gif\" alt=\".\" style=\"background-color: #F7F7F7; background-color: inherit\" title=\"Data Type\" class=\"hierarchy\"/> <a href=\"StructureDefinition-SystemicTreatment-definitions.html#SystemicTreatment.intent\" title=\"Clarifies the reasons why systemic therapy is administered\n• Curative chemotherapy is chemotherapy administered with the goal of achieving a complete remission and preventing the recurrence of cancer. \n• Palliative chemotherapy refers to any chemotherapy administration that is not curative but administered simply to decrease tumor load and increase life expectancy. It has been defined also as “…treatment in circumstances where the impact of intervention is insufficient to result in major survival advantage, but does affect improvement in terms of tumor‐related symptoms…”\n\nThis is not mapped into OMOP it is implicit in the procedures\">intent</a><a name=\"SystemicTreatment.intent\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><span style=\"padding-left: 3px; padding-right: 3px; color: white; background-color: red\" title=\"This element has obligations\">O</span></td><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">0..*</td><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a href=\"http://hl7.org/fhir/R4/datatypes.html#CodeableConcept\">CodeableConcept</a></td><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">Intent (O)<br/><table class=\"grid\"><tr><td style=\"font-size: 11px\"><b>Obligations</b></td><td style=\"font-size: 11px\"><b>Actor</b></td></tr><tr><td style=\"font-size: 11px\"><b>SHALL</b>:<span title=\"obligation: handle\">handle</span></td><td style=\"font-size: 11px; opacity: 0.5;\"><a href=\"ActorDefinition-actor-headneck-i4rc.html\">Head and Neck</a></td></tr></table></td></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white\"><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck10.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_datatype.gif\" alt=\".\" style=\"background-color: white; background-color: inherit\" title=\"Data Type\" class=\"hierarchy\"/> <a href=\"StructureDefinition-SystemicTreatment-definitions.html#SystemicTreatment.setting\" title=\"clarifies the context / how the therapy was administered alone or in conjunction with other treatments\n• Neoadjuvant: treatment given as a first step to shrink a tumor before the main treatment, which is usually surgery, is given. Examples of neoadjuvant therapy include chemotherapy, radiation therapy, and hormone therapy. It is a type of induction therapy.\n• Adjuvant: additional cancer treatment given after the primary treatment to lower the risk that the cancer will come back. Adjuvant therapy may include chemotherapy, radiation therapy, hormone therapy, targeted therapy, or biological therapy.\n• Concomitant/concurrent: A treatment that is given at the same time as another (es. Chemotherapy and radiotherapy).\n\nTHIS INFO CAN BE DERIVED AT QUERY TIME\n\n- Adjuvant chemotherapy is any chemo given after surgery in the hope that the chemo will kill off the remaining cancer cells. This is not a vocabulary issue. You have to create a cohort with chemo patient and a prior surgery recently. There is no difference between chemo and adjuvant chemo in terms of what drugs are used.\n- Neoadjuvant chemotherapy is chemo given before surgery, with the idea that the chemo will shrink the cancer enough that it can be removed surgically. Against, still a normal chemo.\n- Palliative chemotherapy is any chemo given to people without the hope of curing them. It’s just for prolonging life. Again, ordinary chemo.\">setting</a><a name=\"SystemicTreatment.setting\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><span style=\"padding-left: 3px; padding-right: 3px; color: white; background-color: red\" title=\"This element has obligations\">O</span></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">0..*</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a href=\"http://hl7.org/fhir/R4/datatypes.html#CodeableConcept\">CodeableConcept</a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">Setting (O)<br/><table class=\"grid\"><tr><td style=\"font-size: 11px\"><b>Obligations</b></td><td style=\"font-size: 11px\"><b>Actor</b></td></tr><tr><td style=\"font-size: 11px\"><b>SHALL</b>:<span title=\"obligation: handle\">handle</span></td><td style=\"font-size: 11px; opacity: 0.5;\"><a href=\"ActorDefinition-actor-headneck-i4rc.html\">Head and Neck</a></td></tr></table></td></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: #F7F7F7\"><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck10.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_datatype.gif\" alt=\".\" style=\"background-color: #F7F7F7; background-color: inherit\" title=\"Data Type\" class=\"hierarchy\"/> <a href=\"StructureDefinition-SystemicTreatment-definitions.html#SystemicTreatment.chemotherapyInfo\" title=\"Information for chemotherapy \nWe need to check it also at query time. So we are deriving the information at query time and we will also perform quality checks. Additionally, do them at normalized table in possible cases.\">chemotherapyInfo</a><a name=\"SystemicTreatment.chemotherapyInfo\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><span style=\"padding-left: 3px; padding-right: 3px; color: white; background-color: red\" title=\"This element has obligations\">O</span></td><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">0..*</td><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a href=\"http://hl7.org/fhir/R4/datatypes.html#CodeableConcept\">CodeableConcept</a></td><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">Chemotherapy info (O)<br/><table class=\"grid\"><tr><td style=\"font-size: 11px\"><b>Obligations</b></td><td style=\"font-size: 11px\"><b>Actor</b></td></tr><tr><td style=\"font-size: 11px\"><b>SHALL</b>:<span title=\"obligation: handle\">handle</span></td><td style=\"font-size: 11px; opacity: 0.5;\"><a href=\"ActorDefinition-actor-sarcoma-i4rc.html\">Sarcoma</a></td></tr></table></td></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white\"><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck10.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_primitive.png\" alt=\".\" style=\"background-color: white; background-color: inherit\" title=\"Primitive Data Type\" class=\"hierarchy\"/> <a href=\"StructureDefinition-SystemicTreatment-definitions.html#SystemicTreatment.startDateSystemicTreatment\" title=\"Specifies when systemic treatment begins \">startDateSystemicTreatment</a><a name=\"SystemicTreatment.startDateSystemicTreatment\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><span style=\"padding-left: 3px; padding-right: 3px; color: white; background-color: red\" title=\"This element has obligations\">O</span></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">1..*</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a href=\"http://hl7.org/fhir/R4/datatypes.html#date\">date</a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">Start date systemic treatment (M)<br/><table class=\"grid\"><tr><td style=\"font-size: 11px\"><b>Obligations</b></td><td style=\"font-size: 11px\"><b>Actor</b></td></tr><tr><td style=\"font-size: 11px\"><b>SHALL</b>:<span title=\"obligation: handle\">handle</span></td><td style=\"font-size: 11px; opacity: 0.5;\"><a href=\"ActorDefinition-actor-headneck-i4rc.html\">Head and Neck</a></td></tr><tr><td style=\"font-size: 11px\"><b>SHALL</b>:<span title=\"obligation: handle\">handle</span></td><td style=\"font-size: 11px; opacity: 0.5;\"><a href=\"ActorDefinition-actor-sarcoma-i4rc.html\">Sarcoma</a></td></tr></table></td></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: #F7F7F7\"><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck10.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_primitive.png\" alt=\".\" style=\"background-color: #F7F7F7; background-color: inherit\" title=\"Primitive Data Type\" class=\"hierarchy\"/> <a href=\"StructureDefinition-SystemicTreatment-definitions.html#SystemicTreatment.endDateSystemicTreatment\" title=\"Specifies when systemic treatment ends \">endDateSystemicTreatment</a><a name=\"SystemicTreatment.endDateSystemicTreatment\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><span style=\"padding-left: 3px; padding-right: 3px; color: white; background-color: red\" title=\"This element has obligations\">O</span></td><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">1..*</td><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a href=\"http://hl7.org/fhir/R4/datatypes.html#date\">date</a></td><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">End date systemic treatment (M)<br/><table class=\"grid\"><tr><td style=\"font-size: 11px\"><b>Obligations</b></td><td style=\"font-size: 11px\"><b>Actor</b></td></tr><tr><td style=\"font-size: 11px\"><b>SHALL</b>:<span title=\"obligation: handle\">handle</span></td><td style=\"font-size: 11px; opacity: 0.5;\"><a href=\"ActorDefinition-actor-headneck-i4rc.html\">Head and Neck</a></td></tr><tr><td style=\"font-size: 11px\"><b>SHALL</b>:<span title=\"obligation: handle\">handle</span></td><td style=\"font-size: 11px; opacity: 0.5;\"><a href=\"ActorDefinition-actor-sarcoma-i4rc.html\">Sarcoma</a></td></tr></table></td></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white\"><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck10.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_datatype.gif\" alt=\".\" style=\"background-color: white; background-color: inherit\" title=\"Data Type\" class=\"hierarchy\"/> <a href=\"StructureDefinition-SystemicTreatment-definitions.html#SystemicTreatment.numberOfCycles\" title=\"clarifies how many times the treatment was administered. A cycle of treatment is a period of treatment followed by a period of rest (no treatment). For example, treatment given for one week followed by three weeks of rest is one cycle of treatment. A cycle can be repeated multiple times. \nMaybe Integer?\">numberOfCycles</a><a name=\"SystemicTreatment.numberOfCycles\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><span style=\"padding-left: 3px; padding-right: 3px; color: white; background-color: red\" title=\"This element has obligations\">O</span></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">0..*</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a href=\"http://hl7.org/fhir/R4/datatypes.html#Quantity\">Quantity</a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">Number of cycles/ administrations (O)<br/><table class=\"grid\"><tr><td style=\"font-size: 11px\"><b>Obligations</b></td><td style=\"font-size: 11px\"><b>Actor</b></td></tr><tr><td style=\"font-size: 11px\"><b>SHALL</b>:<span title=\"obligation: handle\">handle</span></td><td style=\"font-size: 11px; opacity: 0.5;\"><a href=\"ActorDefinition-actor-headneck-i4rc.html\">Head and Neck</a></td></tr><tr><td style=\"font-size: 11px\"><b>SHALL</b>:<span title=\"obligation: handle\">handle</span></td><td style=\"font-size: 11px; opacity: 0.5;\"><a href=\"ActorDefinition-actor-sarcoma-i4rc.html\">Sarcoma</a></td></tr></table></td></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: #F7F7F7\"><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck10.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_datatype.gif\" alt=\".\" style=\"background-color: #F7F7F7; background-color: inherit\" title=\"Data Type\" class=\"hierarchy\"/> <a href=\"StructureDefinition-SystemicTreatment-definitions.html#SystemicTreatment.regimen\" title=\"The regimen applied to the patient. If this is not present, or the specific regimen is not listed here, use the DrugsForTreatments entity. \">regimen</a><a name=\"SystemicTreatment.regimen\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><span style=\"padding-left: 3px; padding-right: 3px; color: white; background-color: red\" title=\"This element has obligations\">O</span></td><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">0..*</td><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a href=\"http://hl7.org/fhir/R4/datatypes.html#CodeableConcept\">CodeableConcept</a></td><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">Regimen (O)<br/><table class=\"grid\"><tr><td style=\"font-size: 11px\"><b>Obligations</b></td><td style=\"font-size: 11px\"><b>Actor</b></td></tr><tr><td style=\"font-size: 11px\"><b>SHALL</b>:<span title=\"obligation: handle\">handle</span></td><td style=\"font-size: 11px; opacity: 0.5;\"><a href=\"ActorDefinition-actor-headneck-i4rc.html\">Head and Neck</a></td></tr><tr><td style=\"font-size: 11px\"><b>SHALL</b>:<span title=\"obligation: handle\">handle</span></td><td style=\"font-size: 11px; opacity: 0.5;\"><a href=\"ActorDefinition-actor-sarcoma-i4rc.html\">Sarcoma</a></td></tr></table></td></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white\"><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck10.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_primitive.png\" alt=\".\" style=\"background-color: white; background-color: inherit\" title=\"Primitive Data Type\" class=\"hierarchy\"/> <a href=\"StructureDefinition-SystemicTreatment-definitions.html#SystemicTreatment.startDateRegimenChanged\" title=\"specifies when the new systemic treatment begins, if a combination please specify the start of the first drug \">startDateRegimenChanged</a><a name=\"SystemicTreatment.startDateRegimenChanged\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><span style=\"padding-left: 3px; padding-right: 3px; color: white; background-color: red\" title=\"This element has obligations\">O</span></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">1..*</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a href=\"http://hl7.org/fhir/R4/datatypes.html#date\">date</a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">Start date regimen changed (M)<br/><table class=\"grid\"><tr><td style=\"font-size: 11px\"><b>Obligations</b></td><td style=\"font-size: 11px\"><b>Actor</b></td></tr><tr><td style=\"font-size: 11px\"><b>SHALL</b>:<span title=\"obligation: handle\">handle</span></td><td style=\"font-size: 11px; opacity: 0.5;\"><a href=\"ActorDefinition-actor-headneck-i4rc.html\">Head and Neck</a></td></tr></table></td></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: #F7F7F7\"><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck10.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_primitive.png\" alt=\".\" style=\"background-color: #F7F7F7; background-color: inherit\" title=\"Primitive Data Type\" class=\"hierarchy\"/> <a href=\"StructureDefinition-SystemicTreatment-definitions.html#SystemicTreatment.endDateRegimenChanged\" title=\"specifies when the new  systemic treatment ends,if a combination please specify the end of the last drug \">endDateRegimenChanged</a><a name=\"SystemicTreatment.endDateRegimenChanged\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><span style=\"padding-left: 3px; padding-right: 3px; color: white; background-color: red\" title=\"This element has obligations\">O</span></td><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">1..*</td><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a href=\"http://hl7.org/fhir/R4/datatypes.html#date\">date</a></td><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">End date regimen changed (M)<br/><table class=\"grid\"><tr><td style=\"font-size: 11px\"><b>Obligations</b></td><td style=\"font-size: 11px\"><b>Actor</b></td></tr><tr><td style=\"font-size: 11px\"><b>SHALL</b>:<span title=\"obligation: handle\">handle</span></td><td style=\"font-size: 11px; opacity: 0.5;\"><a href=\"ActorDefinition-actor-headneck-i4rc.html\">Head and Neck</a></td></tr></table></td></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white\"><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck10.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_datatype.gif\" alt=\".\" style=\"background-color: white; background-color: inherit\" title=\"Data Type\" class=\"hierarchy\"/> <a href=\"StructureDefinition-SystemicTreatment-definitions.html#SystemicTreatment.reasonForEndOfTreatment\" title=\"Clarifies the reasons why the treatment ended or was interrupted \nDEATH needs to be found in OMOP by following the standar processes\">reasonForEndOfTreatment</a><a name=\"SystemicTreatment.reasonForEndOfTreatment\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><span style=\"padding-left: 3px; padding-right: 3px; color: white; background-color: red\" title=\"This element has obligations\">O</span></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">1..*</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a href=\"http://hl7.org/fhir/R4/datatypes.html#CodeableConcept\">CodeableConcept</a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">Reason for end of treatment (M)<br/><table class=\"grid\"><tr><td style=\"font-size: 11px\"><b>Obligations</b></td><td style=\"font-size: 11px\"><b>Actor</b></td></tr><tr><td style=\"font-size: 11px\"><b>SHALL</b>:<span title=\"obligation: handle\">handle</span></td><td style=\"font-size: 11px; opacity: 0.5;\"><a href=\"ActorDefinition-actor-headneck-i4rc.html\">Head and Neck</a></td></tr><tr><td style=\"font-size: 11px\"><b>SHALL</b>:<span title=\"obligation: handle\">handle</span></td><td style=\"font-size: 11px; opacity: 0.5;\"><a href=\"ActorDefinition-actor-sarcoma-i4rc.html\">Sarcoma</a></td></tr></table></td></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: #F7F7F7\"><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck00.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin_end.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_datatype.gif\" alt=\".\" style=\"background-color: #F7F7F7; background-color: inherit\" title=\"Data Type\" class=\"hierarchy\"/> <a href=\"StructureDefinition-SystemicTreatment-definitions.html#SystemicTreatment.treatmentResponse\" title=\"Measures how well a cancer patient responds to treatment. RECIST criteria should not be applied. The definition of Complete response; Partial response; Stable disease; Progression, should be based on the clinical judgement based on imaging.  Only when setting=neoadiuvant or  palliative \nOLD\n\nComplete response - 4163135\nPartial response -  4161302\nStable disease - 4241442\nProgression - 4168352\n\n&quot;A treatment response is a record of the EPISODE table;\nepisode_start_date is end date of regimen;\nepisode_object_concept_id is the overarching sarcoma&quot;\n\n\n\n\">treatmentResponse</a><a name=\"SystemicTreatment.treatmentResponse\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><span style=\"padding-left: 3px; padding-right: 3px; color: white; background-color: red\" title=\"This element has obligations\">O</span></td><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">1..*</td><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a href=\"http://hl7.org/fhir/R4/datatypes.html#CodeableConcept\">CodeableConcept</a></td><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">Treatment response (based on imaging alone; no recist or other criteria) (M)<br/><table class=\"grid\"><tr><td style=\"font-size: 11px\"><b>Obligations</b></td><td style=\"font-size: 11px\"><b>Actor</b></td></tr><tr><td style=\"font-size: 11px\"><b>SHALL</b>:<span title=\"obligation: handle\">handle</span></td><td style=\"font-size: 11px; opacity: 0.5;\"><a href=\"ActorDefinition-actor-headneck-i4rc.html\">Head and Neck</a></td></tr><tr><td style=\"font-size: 11px\"><b>SHALL</b>:<span title=\"obligation: handle\">handle</span></td><td style=\"font-size: 11px; opacity: 0.5;\"><a href=\"ActorDefinition-actor-sarcoma-i4rc.html\">Sarcoma</a></td></tr></table></td></tr>\r\n<tr><td colspan=\"5\" class=\"hierarchy\"><br/><a href=\"https://build.fhir.org/ig/FHIR/ig-guidance/readingIgs.html#table-views\" title=\"Legend for this format\"><img src=\"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAABAAAAAQCAYAAAAf8/9hAAAABmJLR0QA/wD/AP+gvaeTAAAACXBIWXMAAAsTAAALEwEAmpwYAAAAB3RJTUUH3goXBCwdPqAP0wAAAldJREFUOMuNk0tIlFEYhp9z/vE2jHkhxXA0zJCMitrUQlq4lnSltEqCFhFG2MJFhIvIFpkEWaTQqjaWZRkp0g26URZkTpbaaOJkDqk10szoODP//7XIMUe0elcfnPd9zsfLOYplGrpRwZaqTtw3K7PtGem7Q6FoidbGgqHVy/HRb669R+56zx7eRV1L31JGxYbBtjKK93cxeqfyQHbehkZbUkK20goELEuIzEd+dHS+qz/Y8PTSif0FnGkbiwcAjHaU1+QWOptFiyCLp/LnKptpqIuXHx6rbR26kJcBX3yLgBfnd7CxwJmflpP2wUg0HIAoUUpZBmKzELGWcN8nAr6Gpu7tLU/CkwAaoKTWRSQyt89Q8w6J+oVQkKnBoblH7V0PPvUOvDYXfopE/SJmALsxnVm6LbkotrUtNowMeIrVrBcBpaMmdS0j9df7abpSuy7HWehwJdt1lhVwi/J58U5beXGAF6c3UXLycw1wdFklArBn87xdh0ZsZtArghBdAA3+OEDVubG4UEzP6x1FOWneHh2VDAHBAt80IbdXDcesNoCvs3E5AFyNSU5nbrDPZpcUEQQTFZiEVx+51fxMhhyJEAgvlriadIJZZksRuwBYMOPBbO3hePVVqgEJhFeUuFLhIPkRP6BQLIBrmMenujm/3g4zc398awIe90Zb5A1vREALqneMcYgP/xVQWlG+Ncu5vgwwlaUNx+3799rfe96u9K0JSDXcOzOTJg4B6IgmXfsygc7/Bvg9g9E58/cDVmGIBOP/zT8Bz1zqWqpbXIsd0O9hajXfL6u4BaOS6SeWAAAAAElFTkSuQmCC\" alt=\"doco\" style=\"background-color: inherit\"/> Documentation for this format</a></td></tr></table></div>"
  },
  "url" : "http://hl7.eu/fhir/ig/idea4rc/StructureDefinition/SystemicTreatment",
  "version" : "0.1.0",
  "name" : "SystemicTreatmentI4RC",
  "title" : "Systemic Treatment",
  "status" : "draft",
  "date" : "2025-01-13T10:15:12+00:00",
  "publisher" : "IDEA4RC Project",
  "contact" : [
    {
      "name" : "IDEA4RC Project",
      "telecom" : [
        {
          "system" : "url",
          "value" : "https://www.idea4rc.eu/"
        }
      ]
    },
    {
      "name" : "IDEA4RC Project",
      "telecom" : [
        {
          "system" : "url",
          "value" : "https://www.idea4rc.eu/"
        }
      ]
    }
  ],
  "description" : "Systemic Treatment\nMaturity Level: 0 Draft",
  "jurisdiction" : [
    {
      "coding" : [
        {
          "system" : "http://unstats.un.org/unsd/methods/m49/m49.htm",
          "code" : "150",
          "display" : "Europe"
        }
      ]
    }
  ],
  "fhirVersion" : "4.0.1",
  "kind" : "logical",
  "abstract" : false,
  "type" : "http://hl7.eu/fhir/ig/idea4rc/StructureDefinition/SystemicTreatment",
  "baseDefinition" : "http://hl7.org/fhir/StructureDefinition/Base",
  "derivation" : "specialization",
  "snapshot" : {
    "element" : [
      {
        "id" : "SystemicTreatment",
        "path" : "SystemicTreatment",
        "short" : "Systemic Treatment",
        "definition" : "Systemic Treatment\nMaturity Level: 0 Draft",
        "min" : 0,
        "max" : "*",
        "base" : {
          "path" : "Base",
          "min" : 0,
          "max" : "*"
        },
        "isModifier" : false
      },
      {
        "id" : "SystemicTreatment.diagnosisReference",
        "extension" : [
          {
            "extension" : [
              {
                "url" : "code",
                "valueCode" : "SHALL:handle"
              },
              {
                "url" : "actor",
                "valueCanonical" : "http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc"
              }
            ],
            "url" : "http://hl7.org/fhir/StructureDefinition/obligation"
          },
          {
            "extension" : [
              {
                "url" : "code",
                "valueCode" : "SHALL:handle"
              },
              {
                "url" : "actor",
                "valueCanonical" : "http://hl7.eu/fhir/ig/idea4rc/actor-sarcoma-i4rc"
              }
            ],
            "url" : "http://hl7.org/fhir/StructureDefinition/obligation"
          }
        ],
        "path" : "SystemicTreatment.diagnosisReference",
        "short" : "Diagnosis reference (M)",
        "definition" : "Diagnosis reference in case the treatment was done for baseline",
        "min" : 1,
        "max" : "*",
        "base" : {
          "path" : "SystemicTreatment.diagnosisReference",
          "min" : 1,
          "max" : "*"
        },
        "type" : [
          {
            "code" : "http://hl7.eu/fhir/ig/idea4rc/StructureDefinition/Diagnosis"
          }
        ]
      },
      {
        "id" : "SystemicTreatment.episodeEvent",
        "extension" : [
          {
            "extension" : [
              {
                "url" : "code",
                "valueCode" : "SHALL:handle"
              },
              {
                "url" : "actor",
                "valueCanonical" : "http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc"
              }
            ],
            "url" : "http://hl7.org/fhir/StructureDefinition/obligation"
          },
          {
            "extension" : [
              {
                "url" : "code",
                "valueCode" : "SHALL:handle"
              },
              {
                "url" : "actor",
                "valueCanonical" : "http://hl7.eu/fhir/ig/idea4rc/actor-sarcoma-i4rc"
              }
            ],
            "url" : "http://hl7.org/fhir/StructureDefinition/obligation"
          }
        ],
        "path" : "SystemicTreatment.episodeEvent",
        "short" : "Episode Event reference (M)",
        "definition" : "EpisodeEvent element containing the data regarding the patient's cancer",
        "min" : 1,
        "max" : "*",
        "base" : {
          "path" : "SystemicTreatment.episodeEvent",
          "min" : 1,
          "max" : "*"
        },
        "type" : [
          {
            "code" : "http://hl7.eu/fhir/ig/idea4rc/StructureDefinition/EpisodeEvent"
          }
        ]
      },
      {
        "id" : "SystemicTreatment.systemicTreatmentHospital",
        "extension" : [
          {
            "extension" : [
              {
                "url" : "code",
                "valueCode" : "SHALL:handle"
              },
              {
                "url" : "actor",
                "valueCanonical" : "http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc"
              }
            ],
            "url" : "http://hl7.org/fhir/StructureDefinition/obligation"
          },
          {
            "extension" : [
              {
                "url" : "code",
                "valueCode" : "SHALL:handle"
              },
              {
                "url" : "actor",
                "valueCanonical" : "http://hl7.eu/fhir/ig/idea4rc/actor-sarcoma-i4rc"
              }
            ],
            "url" : "http://hl7.org/fhir/StructureDefinition/obligation"
          }
        ],
        "path" : "SystemicTreatment.systemicTreatmentHospital",
        "short" : "SystemicTreatment Hospital (M)",
        "definition" : "In which hospital was the SystemicTreatment performed",
        "min" : 1,
        "max" : "*",
        "base" : {
          "path" : "SystemicTreatment.systemicTreatmentHospital",
          "min" : 1,
          "max" : "*"
        },
        "type" : [
          {
            "code" : "string"
          }
        ]
      },
      {
        "id" : "SystemicTreatment.typeOfSystemicTreatment",
        "extension" : [
          {
            "extension" : [
              {
                "url" : "code",
                "valueCode" : "SHALL:handle"
              },
              {
                "url" : "actor",
                "valueCanonical" : "http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc"
              }
            ],
            "url" : "http://hl7.org/fhir/StructureDefinition/obligation"
          },
          {
            "extension" : [
              {
                "url" : "code",
                "valueCode" : "SHALL:handle"
              },
              {
                "url" : "actor",
                "valueCanonical" : "http://hl7.eu/fhir/ig/idea4rc/actor-sarcoma-i4rc"
              }
            ],
            "url" : "http://hl7.org/fhir/StructureDefinition/obligation"
          }
        ],
        "path" : "SystemicTreatment.typeOfSystemicTreatment",
        "short" : "type of systemic treatment (M)",
        "definition" : "Select the type of systemic treatment administered. It is possible to directly select the single treatment as appropriate. \nCheck Targeted therapy code",
        "comment" : "Chemotherapy - 4273629\nImmunotherapy - 40310107\nTargeted therapy -  912065",
        "min" : 1,
        "max" : "*",
        "base" : {
          "path" : "SystemicTreatment.typeOfSystemicTreatment",
          "min" : 1,
          "max" : "*"
        },
        "type" : [
          {
            "code" : "CodeableConcept"
          }
        ]
      },
      {
        "id" : "SystemicTreatment.intent",
        "extension" : [
          {
            "extension" : [
              {
                "url" : "code",
                "valueCode" : "SHALL:handle"
              },
              {
                "url" : "actor",
                "valueCanonical" : "http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc"
              }
            ],
            "url" : "http://hl7.org/fhir/StructureDefinition/obligation"
          }
        ],
        "path" : "SystemicTreatment.intent",
        "short" : "Intent (O)",
        "definition" : "Clarifies the reasons why systemic therapy is administered\n• Curative chemotherapy is chemotherapy administered with the goal of achieving a complete remission and preventing the recurrence of cancer. \n• Palliative chemotherapy refers to any chemotherapy administration that is not curative but administered simply to decrease tumor load and increase life expectancy. It has been defined also as “…treatment in circumstances where the impact of intervention is insufficient to result in major survival advantage, but does affect improvement in terms of tumor‐related symptoms…”\n\nThis is not mapped into OMOP it is implicit in the procedures",
        "comment" : "Palliative - 4179711\nCurative procedure intent - 4162591",
        "min" : 0,
        "max" : "*",
        "base" : {
          "path" : "SystemicTreatment.intent",
          "min" : 0,
          "max" : "*"
        },
        "type" : [
          {
            "code" : "CodeableConcept"
          }
        ]
      },
      {
        "id" : "SystemicTreatment.setting",
        "extension" : [
          {
            "extension" : [
              {
                "url" : "code",
                "valueCode" : "SHALL:handle"
              },
              {
                "url" : "actor",
                "valueCanonical" : "http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc"
              }
            ],
            "url" : "http://hl7.org/fhir/StructureDefinition/obligation"
          }
        ],
        "path" : "SystemicTreatment.setting",
        "short" : "Setting (O)",
        "definition" : "clarifies the context / how the therapy was administered alone or in conjunction with other treatments\n• Neoadjuvant: treatment given as a first step to shrink a tumor before the main treatment, which is usually surgery, is given. Examples of neoadjuvant therapy include chemotherapy, radiation therapy, and hormone therapy. It is a type of induction therapy.\n• Adjuvant: additional cancer treatment given after the primary treatment to lower the risk that the cancer will come back. Adjuvant therapy may include chemotherapy, radiation therapy, hormone therapy, targeted therapy, or biological therapy.\n• Concomitant/concurrent: A treatment that is given at the same time as another (es. Chemotherapy and radiotherapy).\n\nTHIS INFO CAN BE DERIVED AT QUERY TIME\n\n- Adjuvant chemotherapy is any chemo given after surgery in the hope that the chemo will kill off the remaining cancer cells. This is not a vocabulary issue. You have to create a cohort with chemo patient and a prior surgery recently. There is no difference between chemo and adjuvant chemo in terms of what drugs are used.\n- Neoadjuvant chemotherapy is chemo given before surgery, with the idea that the chemo will shrink the cancer enough that it can be removed surgically. Against, still a normal chemo.\n- Palliative chemotherapy is any chemo given to people without the hope of curing them. It’s just for prolonging life. Again, ordinary chemo.",
        "comment" : "Neo-adjuvant - 44808409\nConcomitant - 2000100028\n Adjuvant - 44804498\nSystemic treatment alone - 2000100029",
        "min" : 0,
        "max" : "*",
        "base" : {
          "path" : "SystemicTreatment.setting",
          "min" : 0,
          "max" : "*"
        },
        "type" : [
          {
            "code" : "CodeableConcept"
          }
        ]
      },
      {
        "id" : "SystemicTreatment.chemotherapyInfo",
        "extension" : [
          {
            "extension" : [
              {
                "url" : "code",
                "valueCode" : "SHALL:handle"
              },
              {
                "url" : "actor",
                "valueCanonical" : "http://hl7.eu/fhir/ig/idea4rc/actor-sarcoma-i4rc"
              }
            ],
            "url" : "http://hl7.org/fhir/StructureDefinition/obligation"
          }
        ],
        "path" : "SystemicTreatment.chemotherapyInfo",
        "short" : "Chemotherapy info (O)",
        "definition" : "Information for chemotherapy \nWe need to check it also at query time. So we are deriving the information at query time and we will also perform quality checks. Additionally, do them at normalized table in possible cases.",
        "comment" : "Preoperative - 4119031\nPostoperative period - 4118656\nHyperthermic intraperitoneal chemotherapy - 3184898\nTherapeutic - 4133895",
        "min" : 0,
        "max" : "*",
        "base" : {
          "path" : "SystemicTreatment.chemotherapyInfo",
          "min" : 0,
          "max" : "*"
        },
        "type" : [
          {
            "code" : "CodeableConcept"
          }
        ]
      },
      {
        "id" : "SystemicTreatment.startDateSystemicTreatment",
        "extension" : [
          {
            "extension" : [
              {
                "url" : "code",
                "valueCode" : "SHALL:handle"
              },
              {
                "url" : "actor",
                "valueCanonical" : "http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc"
              }
            ],
            "url" : "http://hl7.org/fhir/StructureDefinition/obligation"
          },
          {
            "extension" : [
              {
                "url" : "code",
                "valueCode" : "SHALL:handle"
              },
              {
                "url" : "actor",
                "valueCanonical" : "http://hl7.eu/fhir/ig/idea4rc/actor-sarcoma-i4rc"
              }
            ],
            "url" : "http://hl7.org/fhir/StructureDefinition/obligation"
          }
        ],
        "path" : "SystemicTreatment.startDateSystemicTreatment",
        "short" : "Start date systemic treatment (M)",
        "definition" : "Specifies when systemic treatment begins",
        "min" : 1,
        "max" : "*",
        "base" : {
          "path" : "SystemicTreatment.startDateSystemicTreatment",
          "min" : 1,
          "max" : "*"
        },
        "type" : [
          {
            "code" : "date"
          }
        ]
      },
      {
        "id" : "SystemicTreatment.endDateSystemicTreatment",
        "extension" : [
          {
            "extension" : [
              {
                "url" : "code",
                "valueCode" : "SHALL:handle"
              },
              {
                "url" : "actor",
                "valueCanonical" : "http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc"
              }
            ],
            "url" : "http://hl7.org/fhir/StructureDefinition/obligation"
          },
          {
            "extension" : [
              {
                "url" : "code",
                "valueCode" : "SHALL:handle"
              },
              {
                "url" : "actor",
                "valueCanonical" : "http://hl7.eu/fhir/ig/idea4rc/actor-sarcoma-i4rc"
              }
            ],
            "url" : "http://hl7.org/fhir/StructureDefinition/obligation"
          }
        ],
        "path" : "SystemicTreatment.endDateSystemicTreatment",
        "short" : "End date systemic treatment (M)",
        "definition" : "Specifies when systemic treatment ends",
        "min" : 1,
        "max" : "*",
        "base" : {
          "path" : "SystemicTreatment.endDateSystemicTreatment",
          "min" : 1,
          "max" : "*"
        },
        "type" : [
          {
            "code" : "date"
          }
        ]
      },
      {
        "id" : "SystemicTreatment.numberOfCycles",
        "extension" : [
          {
            "extension" : [
              {
                "url" : "code",
                "valueCode" : "SHALL:handle"
              },
              {
                "url" : "actor",
                "valueCanonical" : "http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc"
              }
            ],
            "url" : "http://hl7.org/fhir/StructureDefinition/obligation"
          },
          {
            "extension" : [
              {
                "url" : "code",
                "valueCode" : "SHALL:handle"
              },
              {
                "url" : "actor",
                "valueCanonical" : "http://hl7.eu/fhir/ig/idea4rc/actor-sarcoma-i4rc"
              }
            ],
            "url" : "http://hl7.org/fhir/StructureDefinition/obligation"
          }
        ],
        "path" : "SystemicTreatment.numberOfCycles",
        "short" : "Number of cycles/ administrations (O)",
        "definition" : "clarifies how many times the treatment was administered. A cycle of treatment is a period of treatment followed by a period of rest (no treatment). For example, treatment given for one week followed by three weeks of rest is one cycle of treatment. A cycle can be repeated multiple times. \nMaybe Integer?",
        "min" : 0,
        "max" : "*",
        "base" : {
          "path" : "SystemicTreatment.numberOfCycles",
          "min" : 0,
          "max" : "*"
        },
        "type" : [
          {
            "code" : "Quantity"
          }
        ]
      },
      {
        "id" : "SystemicTreatment.regimen",
        "extension" : [
          {
            "extension" : [
              {
                "url" : "code",
                "valueCode" : "SHALL:handle"
              },
              {
                "url" : "actor",
                "valueCanonical" : "http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc"
              }
            ],
            "url" : "http://hl7.org/fhir/StructureDefinition/obligation"
          },
          {
            "extension" : [
              {
                "url" : "code",
                "valueCode" : "SHALL:handle"
              },
              {
                "url" : "actor",
                "valueCanonical" : "http://hl7.eu/fhir/ig/idea4rc/actor-sarcoma-i4rc"
              }
            ],
            "url" : "http://hl7.org/fhir/StructureDefinition/obligation"
          }
        ],
        "path" : "SystemicTreatment.regimen",
        "short" : "Regimen (O)",
        "definition" : "The regimen applied to the patient. If this is not present, or the specific regimen is not listed here, use the DrugsForTreatments entity.",
        "comment" : "Doxorubicin and Ifosfamide - 35806965\nIfosfamide and Paclitaxel - 35805248\ndoxorubicin and vincristine - 2000100054\nEpirubicin monotherapy - 35804228\nEtoposide monotherapy - 35803691\nGemcitabine monotherapy - 35804135\nIfosfamide and Gemcitabine - 35806435\ngemcitabine and vincristine - 2000100055\nhigh dose cisplatin - 2000100056\nIfosfamide monotherapy - 35804542\nifosfamide and etoposide - 2000100057\nIrinotecan liposomal monotherapy - 35805368\nLenvatinib monotherapy - 35805795\nMethotrexate monotherapy - 35804095\nNivolumab monotherapy - 35803677\nADT (other androgen deprivation therapy) - 35806821\nOxaliplatin monotherapy - 35805078\nPaclitaxel monotherapy - 35804166\nGemcitabine and Paclitaxel - 35804158\nIfosfamide and Paclitaxel - 35805248\nPaclitaxel and Trastuzumab (TH) - 35804201\nPaclitaxel and Vinorelbine - 35101452\n  Pembrolizumab monotherapy - 35803678\nSorafenib monotherapy - 35803487\nTrastuzumab emtansine monotherapy (TDM1) - 35805230\nTrastuzumab monotherapy - 35804222\nVinorelbine monotherapy - 35804241\nweekly carboplatin - 2000100058\nweekly cisplatin - 2000100059\n\nEpirubicin and Ifosfamide - 35806948\nVincristine and Doxorubicin and Ifosfamide - 2000100060\nVincristine,  Actinomycin D, Ifosfamide (\nVAI) - 35805452\nDocetaxel and Gemcitabine - 35803577\nDacarbazine and Doxorubicin - 35806964\nMethotrexate and Doxorubicin and Cisplatin - 2000100061\nMethotrexate and Doxorubicin and Ifosfamide - 2000100062\nDoxorubicin and Cisplatin and Ifosfamide - 2000100063\nCisplatin and Doxorubicin - 35804819\nMethotrexate and Vinorelbine - 2000100064\nIfosfamide and Etoposide (IE) - 35805454\nVincristine and Doxorubicin and Cyclophosphamide - 2000100065\nCyclophosphamide and Etoposide - 35806476\nDoxorubicin and Ifosfamide and Dacarbazine - 2000100066\nDacarbazine and Gemcitabine - 35806969\nCyclophosphamide and Topotecan - 35805453\nIrinotecan and Vincristine - 2000100067\nIrinotecan and Temozolomide - 35805455\nBusulfan and Melphalan - 35804000\nTNF and Melphalan - 2000100068\nCyclophosphamide and Vinorelbine - 2000100069\nVincristine, Ifosfamide, Doxorubicin, Etoposide (VIDE) - 35805451\nPazopanib monotherapy - 35805690\nRegorafenib monotherapy - 35804569\nhigh dose Ifosfamide - 2000100070",
        "min" : 0,
        "max" : "*",
        "base" : {
          "path" : "SystemicTreatment.regimen",
          "min" : 0,
          "max" : "*"
        },
        "type" : [
          {
            "code" : "CodeableConcept"
          }
        ]
      },
      {
        "id" : "SystemicTreatment.startDateRegimenChanged",
        "extension" : [
          {
            "extension" : [
              {
                "url" : "code",
                "valueCode" : "SHALL:handle"
              },
              {
                "url" : "actor",
                "valueCanonical" : "http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc"
              }
            ],
            "url" : "http://hl7.org/fhir/StructureDefinition/obligation"
          }
        ],
        "path" : "SystemicTreatment.startDateRegimenChanged",
        "short" : "Start date regimen changed (M)",
        "definition" : "specifies when the new systemic treatment begins, if a combination please specify the start of the first drug",
        "min" : 1,
        "max" : "*",
        "base" : {
          "path" : "SystemicTreatment.startDateRegimenChanged",
          "min" : 1,
          "max" : "*"
        },
        "type" : [
          {
            "code" : "date"
          }
        ]
      },
      {
        "id" : "SystemicTreatment.endDateRegimenChanged",
        "extension" : [
          {
            "extension" : [
              {
                "url" : "code",
                "valueCode" : "SHALL:handle"
              },
              {
                "url" : "actor",
                "valueCanonical" : "http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc"
              }
            ],
            "url" : "http://hl7.org/fhir/StructureDefinition/obligation"
          }
        ],
        "path" : "SystemicTreatment.endDateRegimenChanged",
        "short" : "End date regimen changed (M)",
        "definition" : "specifies when the new  systemic treatment ends,if a combination please specify the end of the last drug",
        "min" : 1,
        "max" : "*",
        "base" : {
          "path" : "SystemicTreatment.endDateRegimenChanged",
          "min" : 1,
          "max" : "*"
        },
        "type" : [
          {
            "code" : "date"
          }
        ]
      },
      {
        "id" : "SystemicTreatment.reasonForEndOfTreatment",
        "extension" : [
          {
            "extension" : [
              {
                "url" : "code",
                "valueCode" : "SHALL:handle"
              },
              {
                "url" : "actor",
                "valueCanonical" : "http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc"
              }
            ],
            "url" : "http://hl7.org/fhir/StructureDefinition/obligation"
          },
          {
            "extension" : [
              {
                "url" : "code",
                "valueCode" : "SHALL:handle"
              },
              {
                "url" : "actor",
                "valueCanonical" : "http://hl7.eu/fhir/ig/idea4rc/actor-sarcoma-i4rc"
              }
            ],
            "url" : "http://hl7.org/fhir/StructureDefinition/obligation"
          }
        ],
        "path" : "SystemicTreatment.reasonForEndOfTreatment",
        "short" : "Reason for end of treatment (M)",
        "definition" : "Clarifies the reasons why the treatment ended or was interrupted \nDEATH needs to be found in OMOP by following the standar processes",
        "comment" : "Completed successfully - 44788181\nChemotherapy changed acute chemotherapy toxicity - 4162594 \nTreatment ended due to comorbidity - 2000100030\nIntolerance to drug - 4240582\nProcedure discontinued by patient - 37017062\nDeath - 4306655",
        "min" : 1,
        "max" : "*",
        "base" : {
          "path" : "SystemicTreatment.reasonForEndOfTreatment",
          "min" : 1,
          "max" : "*"
        },
        "type" : [
          {
            "code" : "CodeableConcept"
          }
        ]
      },
      {
        "id" : "SystemicTreatment.treatmentResponse",
        "extension" : [
          {
            "extension" : [
              {
                "url" : "code",
                "valueCode" : "SHALL:handle"
              },
              {
                "url" : "actor",
                "valueCanonical" : "http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc"
              }
            ],
            "url" : "http://hl7.org/fhir/StructureDefinition/obligation"
          },
          {
            "extension" : [
              {
                "url" : "code",
                "valueCode" : "SHALL:handle"
              },
              {
                "url" : "actor",
                "valueCanonical" : "http://hl7.eu/fhir/ig/idea4rc/actor-sarcoma-i4rc"
              }
            ],
            "url" : "http://hl7.org/fhir/StructureDefinition/obligation"
          }
        ],
        "path" : "SystemicTreatment.treatmentResponse",
        "short" : "Treatment response (based on imaging alone; no recist or other criteria) (M)",
        "definition" : "Measures how well a cancer patient responds to treatment. RECIST criteria should not be applied. The definition of Complete response; Partial response; Stable disease; Progression, should be based on the clinical judgement based on imaging.  Only when setting=neoadiuvant or  palliative \nOLD\n\nComplete response - 4163135\nPartial response -  4161302\nStable disease - 4241442\nProgression - 4168352\n\n\"A treatment response is a record of the EPISODE table;\nepisode_start_date is end date of regimen;\nepisode_object_concept_id is the overarching sarcoma\"",
        "comment" : "Complete Remission - 32946\nPartial Remission - 32947\nStable Disease - 32948\nProgression - 32949\nNot applicable - 4294169 (Not usable in OMOP)",
        "min" : 1,
        "max" : "*",
        "base" : {
          "path" : "SystemicTreatment.treatmentResponse",
          "min" : 1,
          "max" : "*"
        },
        "type" : [
          {
            "code" : "CodeableConcept"
          }
        ]
      }
    ]
  },
  "differential" : {
    "element" : [
      {
        "id" : "SystemicTreatment",
        "path" : "SystemicTreatment",
        "short" : "Systemic Treatment",
        "definition" : "Systemic Treatment\nMaturity Level: 0 Draft"
      },
      {
        "id" : "SystemicTreatment.diagnosisReference",
        "extension" : [
          {
            "extension" : [
              {
                "url" : "code",
                "valueCode" : "SHALL:handle"
              },
              {
                "url" : "actor",
                "valueCanonical" : "http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc"
              }
            ],
            "url" : "http://hl7.org/fhir/StructureDefinition/obligation"
          },
          {
            "extension" : [
              {
                "url" : "code",
                "valueCode" : "SHALL:handle"
              },
              {
                "url" : "actor",
                "valueCanonical" : "http://hl7.eu/fhir/ig/idea4rc/actor-sarcoma-i4rc"
              }
            ],
            "url" : "http://hl7.org/fhir/StructureDefinition/obligation"
          }
        ],
        "path" : "SystemicTreatment.diagnosisReference",
        "short" : "Diagnosis reference (M)",
        "definition" : "Diagnosis reference in case the treatment was done for baseline ",
        "min" : 1,
        "max" : "*",
        "type" : [
          {
            "code" : "http://hl7.eu/fhir/ig/idea4rc/StructureDefinition/Diagnosis"
          }
        ]
      },
      {
        "id" : "SystemicTreatment.episodeEvent",
        "extension" : [
          {
            "extension" : [
              {
                "url" : "code",
                "valueCode" : "SHALL:handle"
              },
              {
                "url" : "actor",
                "valueCanonical" : "http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc"
              }
            ],
            "url" : "http://hl7.org/fhir/StructureDefinition/obligation"
          },
          {
            "extension" : [
              {
                "url" : "code",
                "valueCode" : "SHALL:handle"
              },
              {
                "url" : "actor",
                "valueCanonical" : "http://hl7.eu/fhir/ig/idea4rc/actor-sarcoma-i4rc"
              }
            ],
            "url" : "http://hl7.org/fhir/StructureDefinition/obligation"
          }
        ],
        "path" : "SystemicTreatment.episodeEvent",
        "short" : "Episode Event reference (M)",
        "definition" : "EpisodeEvent element containing the data regarding the patient's cancer ",
        "min" : 1,
        "max" : "*",
        "type" : [
          {
            "code" : "http://hl7.eu/fhir/ig/idea4rc/StructureDefinition/EpisodeEvent"
          }
        ]
      },
      {
        "id" : "SystemicTreatment.systemicTreatmentHospital",
        "extension" : [
          {
            "extension" : [
              {
                "url" : "code",
                "valueCode" : "SHALL:handle"
              },
              {
                "url" : "actor",
                "valueCanonical" : "http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc"
              }
            ],
            "url" : "http://hl7.org/fhir/StructureDefinition/obligation"
          },
          {
            "extension" : [
              {
                "url" : "code",
                "valueCode" : "SHALL:handle"
              },
              {
                "url" : "actor",
                "valueCanonical" : "http://hl7.eu/fhir/ig/idea4rc/actor-sarcoma-i4rc"
              }
            ],
            "url" : "http://hl7.org/fhir/StructureDefinition/obligation"
          }
        ],
        "path" : "SystemicTreatment.systemicTreatmentHospital",
        "short" : "SystemicTreatment Hospital (M)",
        "definition" : "In which hospital was the SystemicTreatment performed ",
        "min" : 1,
        "max" : "*",
        "type" : [
          {
            "code" : "string"
          }
        ]
      },
      {
        "id" : "SystemicTreatment.typeOfSystemicTreatment",
        "extension" : [
          {
            "extension" : [
              {
                "url" : "code",
                "valueCode" : "SHALL:handle"
              },
              {
                "url" : "actor",
                "valueCanonical" : "http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc"
              }
            ],
            "url" : "http://hl7.org/fhir/StructureDefinition/obligation"
          },
          {
            "extension" : [
              {
                "url" : "code",
                "valueCode" : "SHALL:handle"
              },
              {
                "url" : "actor",
                "valueCanonical" : "http://hl7.eu/fhir/ig/idea4rc/actor-sarcoma-i4rc"
              }
            ],
            "url" : "http://hl7.org/fhir/StructureDefinition/obligation"
          }
        ],
        "path" : "SystemicTreatment.typeOfSystemicTreatment",
        "short" : "type of systemic treatment (M)",
        "definition" : "Select the type of systemic treatment administered. It is possible to directly select the single treatment as appropriate. \nCheck Targeted therapy code",
        "comment" : "Chemotherapy - 4273629\nImmunotherapy - 40310107\nTargeted therapy -  912065",
        "min" : 1,
        "max" : "*",
        "type" : [
          {
            "code" : "CodeableConcept"
          }
        ]
      },
      {
        "id" : "SystemicTreatment.intent",
        "extension" : [
          {
            "extension" : [
              {
                "url" : "code",
                "valueCode" : "SHALL:handle"
              },
              {
                "url" : "actor",
                "valueCanonical" : "http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc"
              }
            ],
            "url" : "http://hl7.org/fhir/StructureDefinition/obligation"
          }
        ],
        "path" : "SystemicTreatment.intent",
        "short" : "Intent (O)",
        "definition" : "Clarifies the reasons why systemic therapy is administered\n• Curative chemotherapy is chemotherapy administered with the goal of achieving a complete remission and preventing the recurrence of cancer. \n• Palliative chemotherapy refers to any chemotherapy administration that is not curative but administered simply to decrease tumor load and increase life expectancy. It has been defined also as “…treatment in circumstances where the impact of intervention is insufficient to result in major survival advantage, but does affect improvement in terms of tumor‐related symptoms…”\n\nThis is not mapped into OMOP it is implicit in the procedures",
        "comment" : "Palliative - 4179711\nCurative procedure intent - 4162591",
        "min" : 0,
        "max" : "*",
        "type" : [
          {
            "code" : "CodeableConcept"
          }
        ]
      },
      {
        "id" : "SystemicTreatment.setting",
        "extension" : [
          {
            "extension" : [
              {
                "url" : "code",
                "valueCode" : "SHALL:handle"
              },
              {
                "url" : "actor",
                "valueCanonical" : "http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc"
              }
            ],
            "url" : "http://hl7.org/fhir/StructureDefinition/obligation"
          }
        ],
        "path" : "SystemicTreatment.setting",
        "short" : "Setting (O)",
        "definition" : "clarifies the context / how the therapy was administered alone or in conjunction with other treatments\n• Neoadjuvant: treatment given as a first step to shrink a tumor before the main treatment, which is usually surgery, is given. Examples of neoadjuvant therapy include chemotherapy, radiation therapy, and hormone therapy. It is a type of induction therapy.\n• Adjuvant: additional cancer treatment given after the primary treatment to lower the risk that the cancer will come back. Adjuvant therapy may include chemotherapy, radiation therapy, hormone therapy, targeted therapy, or biological therapy.\n• Concomitant/concurrent: A treatment that is given at the same time as another (es. Chemotherapy and radiotherapy).\n\nTHIS INFO CAN BE DERIVED AT QUERY TIME\n\n- Adjuvant chemotherapy is any chemo given after surgery in the hope that the chemo will kill off the remaining cancer cells. This is not a vocabulary issue. You have to create a cohort with chemo patient and a prior surgery recently. There is no difference between chemo and adjuvant chemo in terms of what drugs are used.\n- Neoadjuvant chemotherapy is chemo given before surgery, with the idea that the chemo will shrink the cancer enough that it can be removed surgically. Against, still a normal chemo.\n- Palliative chemotherapy is any chemo given to people without the hope of curing them. It’s just for prolonging life. Again, ordinary chemo.",
        "comment" : "Neo-adjuvant - 44808409\nConcomitant - 2000100028\n Adjuvant - 44804498\nSystemic treatment alone - 2000100029",
        "min" : 0,
        "max" : "*",
        "type" : [
          {
            "code" : "CodeableConcept"
          }
        ]
      },
      {
        "id" : "SystemicTreatment.chemotherapyInfo",
        "extension" : [
          {
            "extension" : [
              {
                "url" : "code",
                "valueCode" : "SHALL:handle"
              },
              {
                "url" : "actor",
                "valueCanonical" : "http://hl7.eu/fhir/ig/idea4rc/actor-sarcoma-i4rc"
              }
            ],
            "url" : "http://hl7.org/fhir/StructureDefinition/obligation"
          }
        ],
        "path" : "SystemicTreatment.chemotherapyInfo",
        "short" : "Chemotherapy info (O)",
        "definition" : "Information for chemotherapy \nWe need to check it also at query time. So we are deriving the information at query time and we will also perform quality checks. Additionally, do them at normalized table in possible cases.",
        "comment" : "Preoperative - 4119031\nPostoperative period - 4118656\nHyperthermic intraperitoneal chemotherapy - 3184898\nTherapeutic - 4133895",
        "min" : 0,
        "max" : "*",
        "type" : [
          {
            "code" : "CodeableConcept"
          }
        ]
      },
      {
        "id" : "SystemicTreatment.startDateSystemicTreatment",
        "extension" : [
          {
            "extension" : [
              {
                "url" : "code",
                "valueCode" : "SHALL:handle"
              },
              {
                "url" : "actor",
                "valueCanonical" : "http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc"
              }
            ],
            "url" : "http://hl7.org/fhir/StructureDefinition/obligation"
          },
          {
            "extension" : [
              {
                "url" : "code",
                "valueCode" : "SHALL:handle"
              },
              {
                "url" : "actor",
                "valueCanonical" : "http://hl7.eu/fhir/ig/idea4rc/actor-sarcoma-i4rc"
              }
            ],
            "url" : "http://hl7.org/fhir/StructureDefinition/obligation"
          }
        ],
        "path" : "SystemicTreatment.startDateSystemicTreatment",
        "short" : "Start date systemic treatment (M)",
        "definition" : "Specifies when systemic treatment begins ",
        "min" : 1,
        "max" : "*",
        "type" : [
          {
            "code" : "date"
          }
        ]
      },
      {
        "id" : "SystemicTreatment.endDateSystemicTreatment",
        "extension" : [
          {
            "extension" : [
              {
                "url" : "code",
                "valueCode" : "SHALL:handle"
              },
              {
                "url" : "actor",
                "valueCanonical" : "http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc"
              }
            ],
            "url" : "http://hl7.org/fhir/StructureDefinition/obligation"
          },
          {
            "extension" : [
              {
                "url" : "code",
                "valueCode" : "SHALL:handle"
              },
              {
                "url" : "actor",
                "valueCanonical" : "http://hl7.eu/fhir/ig/idea4rc/actor-sarcoma-i4rc"
              }
            ],
            "url" : "http://hl7.org/fhir/StructureDefinition/obligation"
          }
        ],
        "path" : "SystemicTreatment.endDateSystemicTreatment",
        "short" : "End date systemic treatment (M)",
        "definition" : "Specifies when systemic treatment ends ",
        "min" : 1,
        "max" : "*",
        "type" : [
          {
            "code" : "date"
          }
        ]
      },
      {
        "id" : "SystemicTreatment.numberOfCycles",
        "extension" : [
          {
            "extension" : [
              {
                "url" : "code",
                "valueCode" : "SHALL:handle"
              },
              {
                "url" : "actor",
                "valueCanonical" : "http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc"
              }
            ],
            "url" : "http://hl7.org/fhir/StructureDefinition/obligation"
          },
          {
            "extension" : [
              {
                "url" : "code",
                "valueCode" : "SHALL:handle"
              },
              {
                "url" : "actor",
                "valueCanonical" : "http://hl7.eu/fhir/ig/idea4rc/actor-sarcoma-i4rc"
              }
            ],
            "url" : "http://hl7.org/fhir/StructureDefinition/obligation"
          }
        ],
        "path" : "SystemicTreatment.numberOfCycles",
        "short" : "Number of cycles/ administrations (O)",
        "definition" : "clarifies how many times the treatment was administered. A cycle of treatment is a period of treatment followed by a period of rest (no treatment). For example, treatment given for one week followed by three weeks of rest is one cycle of treatment. A cycle can be repeated multiple times. \nMaybe Integer?",
        "min" : 0,
        "max" : "*",
        "type" : [
          {
            "code" : "Quantity"
          }
        ]
      },
      {
        "id" : "SystemicTreatment.regimen",
        "extension" : [
          {
            "extension" : [
              {
                "url" : "code",
                "valueCode" : "SHALL:handle"
              },
              {
                "url" : "actor",
                "valueCanonical" : "http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc"
              }
            ],
            "url" : "http://hl7.org/fhir/StructureDefinition/obligation"
          },
          {
            "extension" : [
              {
                "url" : "code",
                "valueCode" : "SHALL:handle"
              },
              {
                "url" : "actor",
                "valueCanonical" : "http://hl7.eu/fhir/ig/idea4rc/actor-sarcoma-i4rc"
              }
            ],
            "url" : "http://hl7.org/fhir/StructureDefinition/obligation"
          }
        ],
        "path" : "SystemicTreatment.regimen",
        "short" : "Regimen (O)",
        "definition" : "The regimen applied to the patient. If this is not present, or the specific regimen is not listed here, use the DrugsForTreatments entity. ",
        "comment" : "Doxorubicin and Ifosfamide - 35806965\nIfosfamide and Paclitaxel - 35805248\ndoxorubicin and vincristine - 2000100054\nEpirubicin monotherapy - 35804228\nEtoposide monotherapy - 35803691\nGemcitabine monotherapy - 35804135\nIfosfamide and Gemcitabine - 35806435\ngemcitabine and vincristine - 2000100055\nhigh dose cisplatin - 2000100056\nIfosfamide monotherapy - 35804542\nifosfamide and etoposide - 2000100057\nIrinotecan liposomal monotherapy - 35805368\nLenvatinib monotherapy - 35805795\nMethotrexate monotherapy - 35804095\nNivolumab monotherapy - 35803677\nADT (other androgen deprivation therapy) - 35806821\nOxaliplatin monotherapy - 35805078\nPaclitaxel monotherapy - 35804166\nGemcitabine and Paclitaxel - 35804158\nIfosfamide and Paclitaxel - 35805248\nPaclitaxel and Trastuzumab (TH) - 35804201\nPaclitaxel and Vinorelbine - 35101452\n  Pembrolizumab monotherapy - 35803678\nSorafenib monotherapy - 35803487\nTrastuzumab emtansine monotherapy (TDM1) - 35805230\nTrastuzumab monotherapy - 35804222\nVinorelbine monotherapy - 35804241\nweekly carboplatin - 2000100058\nweekly cisplatin - 2000100059\n\nEpirubicin and Ifosfamide - 35806948\nVincristine and Doxorubicin and Ifosfamide - 2000100060\nVincristine,  Actinomycin D, Ifosfamide (\nVAI) - 35805452\nDocetaxel and Gemcitabine - 35803577\nDacarbazine and Doxorubicin - 35806964\nMethotrexate and Doxorubicin and Cisplatin - 2000100061\nMethotrexate and Doxorubicin and Ifosfamide - 2000100062\nDoxorubicin and Cisplatin and Ifosfamide - 2000100063\nCisplatin and Doxorubicin - 35804819\nMethotrexate and Vinorelbine - 2000100064\nIfosfamide and Etoposide (IE) - 35805454\nVincristine and Doxorubicin and Cyclophosphamide - 2000100065\nCyclophosphamide and Etoposide - 35806476\nDoxorubicin and Ifosfamide and Dacarbazine - 2000100066\nDacarbazine and Gemcitabine - 35806969\nCyclophosphamide and Topotecan - 35805453\nIrinotecan and Vincristine - 2000100067\nIrinotecan and Temozolomide - 35805455\nBusulfan and Melphalan - 35804000\nTNF and Melphalan - 2000100068\nCyclophosphamide and Vinorelbine - 2000100069\nVincristine, Ifosfamide, Doxorubicin, Etoposide (VIDE) - 35805451\nPazopanib monotherapy - 35805690\nRegorafenib monotherapy - 35804569\nhigh dose Ifosfamide - 2000100070",
        "min" : 0,
        "max" : "*",
        "type" : [
          {
            "code" : "CodeableConcept"
          }
        ]
      },
      {
        "id" : "SystemicTreatment.startDateRegimenChanged",
        "extension" : [
          {
            "extension" : [
              {
                "url" : "code",
                "valueCode" : "SHALL:handle"
              },
              {
                "url" : "actor",
                "valueCanonical" : "http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc"
              }
            ],
            "url" : "http://hl7.org/fhir/StructureDefinition/obligation"
          }
        ],
        "path" : "SystemicTreatment.startDateRegimenChanged",
        "short" : "Start date regimen changed (M)",
        "definition" : "specifies when the new systemic treatment begins, if a combination please specify the start of the first drug ",
        "min" : 1,
        "max" : "*",
        "type" : [
          {
            "code" : "date"
          }
        ]
      },
      {
        "id" : "SystemicTreatment.endDateRegimenChanged",
        "extension" : [
          {
            "extension" : [
              {
                "url" : "code",
                "valueCode" : "SHALL:handle"
              },
              {
                "url" : "actor",
                "valueCanonical" : "http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc"
              }
            ],
            "url" : "http://hl7.org/fhir/StructureDefinition/obligation"
          }
        ],
        "path" : "SystemicTreatment.endDateRegimenChanged",
        "short" : "End date regimen changed (M)",
        "definition" : "specifies when the new  systemic treatment ends,if a combination please specify the end of the last drug ",
        "min" : 1,
        "max" : "*",
        "type" : [
          {
            "code" : "date"
          }
        ]
      },
      {
        "id" : "SystemicTreatment.reasonForEndOfTreatment",
        "extension" : [
          {
            "extension" : [
              {
                "url" : "code",
                "valueCode" : "SHALL:handle"
              },
              {
                "url" : "actor",
                "valueCanonical" : "http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc"
              }
            ],
            "url" : "http://hl7.org/fhir/StructureDefinition/obligation"
          },
          {
            "extension" : [
              {
                "url" : "code",
                "valueCode" : "SHALL:handle"
              },
              {
                "url" : "actor",
                "valueCanonical" : "http://hl7.eu/fhir/ig/idea4rc/actor-sarcoma-i4rc"
              }
            ],
            "url" : "http://hl7.org/fhir/StructureDefinition/obligation"
          }
        ],
        "path" : "SystemicTreatment.reasonForEndOfTreatment",
        "short" : "Reason for end of treatment (M)",
        "definition" : "Clarifies the reasons why the treatment ended or was interrupted \nDEATH needs to be found in OMOP by following the standar processes",
        "comment" : "Completed successfully - 44788181\nChemotherapy changed acute chemotherapy toxicity - 4162594 \nTreatment ended due to comorbidity - 2000100030\nIntolerance to drug - 4240582\nProcedure discontinued by patient - 37017062\nDeath - 4306655",
        "min" : 1,
        "max" : "*",
        "type" : [
          {
            "code" : "CodeableConcept"
          }
        ]
      },
      {
        "id" : "SystemicTreatment.treatmentResponse",
        "extension" : [
          {
            "extension" : [
              {
                "url" : "code",
                "valueCode" : "SHALL:handle"
              },
              {
                "url" : "actor",
                "valueCanonical" : "http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc"
              }
            ],
            "url" : "http://hl7.org/fhir/StructureDefinition/obligation"
          },
          {
            "extension" : [
              {
                "url" : "code",
                "valueCode" : "SHALL:handle"
              },
              {
                "url" : "actor",
                "valueCanonical" : "http://hl7.eu/fhir/ig/idea4rc/actor-sarcoma-i4rc"
              }
            ],
            "url" : "http://hl7.org/fhir/StructureDefinition/obligation"
          }
        ],
        "path" : "SystemicTreatment.treatmentResponse",
        "short" : "Treatment response (based on imaging alone; no recist or other criteria) (M)",
        "definition" : "Measures how well a cancer patient responds to treatment. RECIST criteria should not be applied. The definition of Complete response; Partial response; Stable disease; Progression, should be based on the clinical judgement based on imaging.  Only when setting=neoadiuvant or  palliative \nOLD\n\nComplete response - 4163135\nPartial response -  4161302\nStable disease - 4241442\nProgression - 4168352\n\n\"A treatment response is a record of the EPISODE table;\nepisode_start_date is end date of regimen;\nepisode_object_concept_id is the overarching sarcoma\"\n\n\n\n",
        "comment" : "Complete Remission - 32946\nPartial Remission - 32947\nStable Disease - 32948\nProgression - 32949\nNot applicable - 4294169 (Not usable in OMOP)",
        "min" : 1,
        "max" : "*",
        "type" : [
          {
            "code" : "CodeableConcept"
          }
        ]
      }
    ]
  }
}

XIG built as of ??metadata-date??. Found ??metadata-resources?? resources in ??metadata-packages?? packages.